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KMID : 0378019780210040089
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New Medical Journal
1978 Volume.21 No. 4 p.89 ~ p.97
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Hypotensive Action of Coptis rhizoma, Alismatis rhizoma and Acanthopanis cortex radicis in Rat
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이상복/Lee, S.B.
김옥녀/조병현/조규철/Kim, O.N./Cho, B.H./Cho, K.C.
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Abstract
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For the purpose of searching the new antihypertensive agent in the botanical crude drugs, authors intended to determine whether several crude drugs might manifest the hypotensive effect and to clarify the mechanism of this hypotensive agent. This experiment was studied on the hypotensive action with Coptis rhizoma crystal(CR), ethanol extract Alismatis rhizoma (AREE) and ethanol extract of Acanthopanis cortex radicis (ACEE) in the rat. The results of the experiment were as follows: 1) Blood pressure manifested gradual responses by the fall of ?28.0mmHg, -64.5mmHg and -84.0mmHg in proportion to the intravenous injection of 2 mg/kg, 5mg/kg and l0mg/kg of CR respectively. 2) The intravenous injection of 50mg/kg and EOmg/kg of AREE manifested the fall of blood pressure as -51.2mmHg and -56.6mmHg respectively. 3) The intravenous injection of 40mg/kg and 80mg/kg of ACEE manifested the fall of blood pressure as -35.5mmHg and -53.5mmHg respectively. 4) The administration of epinephrine 50mg/kg to the rat pretreated with CR 5mg/kg revealed "epinephrine reversal action" by the fall of blood pressure. 5) The administration of AREE 50mg/kg to the rat pretreated with atropine or diphenhydramine inhibited significantly the hypotensive action of AREE slightly. 6) The administration of ACEE 80mg/kg to the rat pretreated with diphenhydramine inhibited the hypotensive action of ACEE significantly.
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